What is the association between H. pylori and development of. Be sure to explain to the patient the expected normal changes experienced during photic stimulation. Tayfun DALBASTI. Photic and idiopathic are types of trigeminal-mediated headshaking. Normal photic driving has long been known to be potentially reduced on the side of a lesion. official website and that any information you provide is encrypted Abnormal response to photic stimulation in Juvenile Myoclonic Epilepsy: An EEG-fMRI study Emanuele Bartolini, Emanuele Bartolini Department of Clinical and Experimental Medicine, University of Pisa, Italy Search for more papers by this author Ilaria Pesaresi, Ilaria Pesaresi Unit of Neuroradiology, Santa Chiara Hospital AOUP, Italy A significant difference was found between the groups both at rest and following photic stimulation in EEG activity. Subjects were instructed to keep their eyes closed throughout. and transmitted securely. This can offer a clue in diagnosing various neurological conditions. eScholarship, California Digital Library, University of California. The bottommost, or aphotic, zone is the region of perpetual darkness that lies beneath the photic zone and includes most of the ocean waters. Eighty seconds of EEG were collected from each subject for each of four experimental conditions: one resting and three photic-driving conditions (2.38, 4.54, and 8.33 Hz). The EEG activity following the photic driving also differentiated the groups. This site needs JavaScript to work properly. Causality Analysis to the Abnormal Subcortical-Cortical Connections in Idiopathic-Generalized Epilepsy. Drug-free schizophrenic male patients (n = 8, mean age = 23.9) and normal male controls (n = 11, mean age = 24.3) were studied. Unable to load your collection due to an error, Unable to load your delegates due to an error. the last is that you have epilepsy that they can find in the left temporal area. Download Free PDF. The patient may see colors or patterns 2. The EEG activity following the photic driving also differentiated the groups. Categorization Photosensitivity is found much more fre- of PPR done in 1992 [5] is used worldwide and quently in pediatric cohorts than in adult patients, the PPR was subclassified in four phenotypically . Although large eye movements could be excluded as confounding factors, the filter could not for certain exclude small eye movements. The PPR could be a final expression of pathogenic phenomena occurring in the striato-thalamocortical system, possibly a core feature of system epilepsy JME. Lennox-Gastaut syndrome (LGS) is a type of epilepsy. Methods In 13 PPR . What is the mechanism action of H. pylori? Epub 2013 Jul 22. The BOLD response to IPS was investigated both in JME and control groups. The photoconvulsive response ( PCR) has three basic subdivisions: the fronto-centrally predominant paroxysmal spike-and-wave discharge (Figures 2 and 3); the posteriorly predominant slow-wave response with or without sharp waves or spikes or with both spikes and sharp waves (Figures 4 and 5); and poorly defined bursts . N2 - Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. When the seizure does not affect awareness, it is known as a simple partial seizure. If you have the reflex, you probably inherited the trait from a parent. Photic stimulation acutely induces the expression of Per genes in the SCN (Albrecht et al., 1997; Shearman et al., 1997; Bae et al., 2001), suggesting their involvement in light-induced circadian shifts. Your child will be asked to lie on a bed or sit in a chair. Eye movement and other movement artifacts were minimized by use of an automatic amplitude threshold filter. Wiley Periodicals, Inc. 2014 International League Against Epilepsy. 2013 Oct;106(3):357-69. doi: 10.1016/j.eplepsyres.2013.06.017. Bookshelf photoparoxysmal response (PPR). The EEG technician will attach electrodes to different locations on the scalp using adhesive paste. Lennox-Gastaut syndrome (LGS) is a type of epilepsy. Sci Rep. 2022 Feb 21;12(1):2785. doi: 10.1038/s41598-022-06324-2. Although large eye movements could be excluded as confounding factors, the filter could not for certain exclude small eye movements. This result was characterized by increased delta activity and decreased alpha activity in schizophrenic patients at rest. 2004 Aug;127(Pt 8):1878-86. doi: 10.1093/brain/awh211. 1990. Patients with LGS experience many different types of seizures including: Tonic - stiffening of the body. The EEG activity following the photic driving also differentiated the groups. A common term for this behavior is called photic driving. Epub 2019 Feb 21. Clipboard, Search History, and several other advanced features are temporarily unavailable. An official website of the United States government. official website and that any information you provide is encrypted PMC it is the type of wave that is associated with seizures, the t-3 is the location. In developmental disorders such as autism, this process may be perturbed leading to abnormal neural connectivity. Huntington's disease (HD) is a neurodegenerative disease caused by a pathologic CAG repeat expansion in the huntingtin gene. However, the underlining mechanism is still open for discussion. Lets learn them! A significant difference was found between the groups both at rest and following photic stimulation in EEG activity. doi: 10.1016/j.yebeh.2012.11.045. HHS Vulnerability Disclosure, Help Before Mine came back as "photic driving" as in "during the photic stimulation there was photic driving in both hemispheres" meaning that the lights were actually stimulating the brain in a negative way. 1989 Dec;30(3):313-24. doi: 10.1016/0165-1781(89)90022-x. Fig. 2021 Jan;52(1):3-28. doi: 10.1177/1550059420954054. The flash rate can vary. This behavior is in response to neuropathic facial pain caused by an abnormal or compromised trigeminal nerve. Eye movement and other movement artifacts were minimized by use of an automatic amplitude threshold filter. Fig. photic zone, surface layer of the ocean that receives sunlight. Responses to intermittent photic stimulation in an individual patient are influenced by the level of alertness and whether the eyes are open, closed, or closing at the . slang. Before Together they form a unique fingerprint. It is well known that the migraine patients indicate abnormal information processing such as photic supersensitivity. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. (1990). Epub 2005 Oct 27. Eye movement and other movement artifacts were minimized by use of an automatic amplitude threshold filter. Clemens B, Pusks S, Besenyei M, Spisk T, Opposits G, Holldy K, Fogarasi A, Fekete I, Emri M. Epilepsy Res. Photosensitivity is common. Careers. The https:// ensures that you are connecting to the Eye movement and other movement artifacts were minimized by use of an automatic amplitude threshold filter. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. Focal slow wave activity on the EEG is indicative of focal cerebral pathology of the underlying brain region. In medicine, Intermittent Photic Stimulation, or IPS, is a form of visual stimulation used in conjunction with electroencephalography to investigate anomalous brain activity triggered by specific visual stimuli, such as flashing lights or patterns. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. The PPR consists of spikes or spike-and-wave discharges that are triggered by intermittent photic stimulation (IPS). Reflexive sneezing induced by light, and sunlight in particular, is estimated to occur in 18 to 35 percent of the population and is known as the photic sneeze reflex (PSR) or the ACHOO (autosomal dominant compulsive helio-ophthalmic outbursts of sneezing) syndrome. Photosynthesis in photic zone In the photic zone, the photosynthesis rate exceeds the respiration rate. The photic driving response in a high-stimulation region of 15 Hz or more (an H-response) is thought to be abnormal, and migraine patients frequently show the H-response during the interictal phase [4]. Drug-free schizophrenic male patients (n=8, mean age=23.9) and normal male controls (n=11, mean age=24.3) were studied. In this zone enough light penetrates the water to allow photosynthesis. When the patient is relaxed with eyes closed, the background is usually characterized by the posteriorly dominant alpha rhythm, also known simply as the posterior dominant rhythm. Most waves of 8 Hz and higher frequencies are normal findings in the EEG of an awake adult. Quantitative EEG analysis at rest and during photic stimulation in drug-naive patients with first-episode paranoid schizophrenia. While these 2 types of nonepileptiform abnormalities often coexist,. The EEG activity following the photic driving also differentiated the groups. 1 : of, relating to, or involving light especially in relation to organisms. Schizophrenic patients had decreased sensitivity to the photic stimulation in the alpha range for spectra derived from both fundamental and harmonic analysis. Juvenile Myoclonic Epilepsy; Neuroimaging; Neurophysiology; Photosensitivity. Psychiatry Res. / Jin, Yi; Potkin, Steven G.; Rice, Dan et al. Please enable it to take advantage of the complete set of features! 8600 Rockville Pike Abstract. Photosensitive seizures can fall under several categories, including tonic-clonic, absence, myoclonic and focal seizures. 2022 Jul 1;101(26):e29625. At least 3 minutes after hyperventilation, all patients had received photic stimulation evoked by light flashes at frequencies of 1,2,8,10 . Ethridge L, Moratti S, Gao Y, Keil A, Clementz BA. BMC Neurol. Eighty seconds of EEG were collected from each subject for each of. Photic headshakers have a distinct . Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. Our aim was to explore the blood oxygen level-dependent (BOLD) response evoked by a highly provocative photic stimulus in a cohort of people with JME compared to a group of nonphotosensitive healthy controls, and to investigate the hemodynamic phenomena seen in patients with photosensitive JME. FULL-LENGTH ORIGINAL RESEARCH Abnormal response to photic stimulation in Juvenile Myoclonic Epilepsy: An EEG-fMRI study *Emanuele Bartolini, Ilaria Pesaresi, *Serena Fabbri, *Paolo Cecchi, Filippo Sean Giorgi, *Ferdinando Sartucci, *Ubaldo Bonuccelli, and Mirco Cosottini Epilepsia, 55(7):1038-1047, 2014 doi: 10.1111/epi.12634 Interictal electroencephalography (EEG) displays 3-6 Hz spike/polyspike and wave pattern. Unable to load your collection due to an error, Unable to load your delegates due to an error. Abnormal response to photic stimulation in Juvenile Myoclonic Epilepsy: An EEGfMRI study, Epilepsia | 10.1111/epi.12634 | DeepDyve Summary Objective Juvenile myoclonic epilepsy (JME) is a youngonset electroclinical syndrome, characterized by myoclonic, generalized tonic-clonic, and possibly typical absence seizures. Eye movement and other movement artifacts were minimized by use of an automatic amplitude threshold filter. Epub 2020 Sep 25. Our photic has a similar lamp shape and brightness to previous class-leading products, but is smaller, more lightweight, and more energy-efficient by utilizing state-of . Photosensitivity is common. Brain. Abnormal Spikes, Multiple Independent Spike Foci & Polyspike on Photic Stimulation Symptom Checker: Possible causes include Lennox-Gastaut Syndrome. and transmitted securely. Therapeutic effects of individualized alpha frequency transcranial magnetic stimulation (alphaTMS) on the negative symptoms of schizophrenia. Epub 2016 Nov 14. In photosensitive JME subjects, we also performed a dynamic evalua- tion of BOLD signal. Although indicatingthe existence of responses to repetitivestimulation, he found photic"driving""relativelyrarely,"in only5% of infants duringtheneonatal period; this phe-nomenon, however, was elicited in 39% of infants 2 weeks of age or over. Rice DM, Potkin SG, Jin Y, Isenhart R, Heh CW, Sramek J, Costa J, Sandman CA. UR - http://www.scopus.com/inward/record.url?scp=0025609792&partnerID=8YFLogxK, UR - http://www.scopus.com/inward/citedby.url?scp=0025609792&partnerID=8YFLogxK, Powered by Pure, Scopus & Elsevier Fingerprint Engine 2022 Elsevier B.V, We use cookies to help provide and enhance our service and tailor content. Intermittent photic stimulation (IPS) is a common procedure performed in the electroencephalography (EEG) laboratory in children and adults to detect abnormal epileptogenic sensitivity to flickering light (i.e., photosensitivity). These seizures can also be triggered by certain patterns such as stripes. Photic stimulation (PS) has been the most commonly used method of cerebral activation in routine EEG exam-inations and is known to be a useful method for eliciting paroxysmal EEG activity (Takahashi 1987). Eighty seconds of EEG were collected from each subject for each of four experimental conditions: one resting and three photic-driving conditions (2.38, 4.54, and 8.33 Hz). The results suggest that schizophrenic patients show fewer changes in posterior alpha activity during both stimulus and nonstimulus, and this continuity of posterior dominance may reflect hyperarousal, which counteracts any decrease in vigilance throughout the IPS. An official website of the United States government. A wide range of experimental and natural visual stimuli may induce a PPR, including flashing light, patterns of lines, or gratings ( Ferlazzo et al., 2005 ). Good luck:) Elizabeth Subjects were instructed to keep their eyes closed throughout. I would asume that "driving reponse" is used to determine how your brain responds to the photic stimulation. Accessibility Results: An EEG can be done in the doctors office, a lab, or a hospital. The photic light should be placed 12 inches or 30 centimeters from the patient's face. Exposure to triggers normally provokes an abnormal response of the brain's electrical circuits called photo-paroxysmal response (PPR) in photosensitive individuals [ 16 ]. Careful analysis of electrophysiological connectivity patterns using EEG coherence may provide a way to probe the resulting differences in neurological function between people with and without autism. sharing sensitive information, make sure youre on a federal All . A significant difference was found between the groups both at rest and following photic stimulation in EEG activity. EEG alpha photic driving abnormalities in chronic schizophrenia. This site needs JavaScript to work properly. Drug-free schizophrenic male patients (n=8, mean age=23.9) and normal male controls (n=11, mean age=24.3) were studied. This result was characterized by increased delta activity and decreased alpha activity in schizophrenic patients at rest. Interictal electroencephalography (EEG) displays 3-6 Hz spike/polyspike and wave pattern. government site. Schizophrenic patients had decreased sensitivity to the photic stimulation in the alpha range for spectra derived from both fundamental and harmonic analysis, and this result was characterized by increased delta activity and decreased alpha activity in schizophrenic patients at rest. The site is secure. . (HAND) with IPS to examine whether patients with idiopathic generalized epilepsy (IGE) exhibit an abnormal cortical response pattern to IPS. Federal government websites often end in .gov or .mil. 2019;22:101693. doi: 10.1016/j.nicl.2019.101693. The frequency of the photic stimulator is eight flashes per second. In children, the main cause of status epilepticus is an infection with a fever. Electroencephalography and clinical neurophysiology, By clicking accept or continuing to use the site, you agree to the terms outlined in our. Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG . 1980 Oct;11(4):180-7. doi: 10.1177/155005948001100407. A partial (focal) seizure happens when unusual electrical activity affects a small area of the brain. 2017 Jan;128(1):176-182. doi: 10.1016/j.clinph.2016.10.098. Shakeshaft A, Panjwani N, Collingwood A, Crudgington H, Hall A, Andrade DM, Beier CP, Fong CY, Gardella E, Gesche J, Greenberg DA, Hamandi K, Koht J, Lim KS, Mller RS, Ng CC, Orsini A, Rees MI, Rubboli G, Selmer KK, Striano P, Syvertsen M, Thomas RH, Zarubova J, Richardson MP, Strug LJ, Pal DK. In occipital structural brain abnormality, background posterior dominant alpha rhythms and photic driving responses may be asymmetric in amplitude; the interictal EEG may or may not show interictal epileptiform abnormality (spike-and-wave or sharp slow waves). Intermittent photic stimulation can also be responsible for physiological photomyogenic electroencephalographic responses, which should be distinguished from the abnormal photoparoxysmal response, which is characterized by generalized spike-and-wave or polyspike-and-wave discharges that can culminate in a clinically overt seizure (Fig. The photic sneeze reflex (also known as Autosomal Dominant Compelling Helio-Ophthalmic Outburst (ACHOO) syndrome or photosneezia, from the Greek , phs, light and colloquially sun sneezing) is a reflex condition that causes sneezing in response to numerous stimuli, such as looking at bright lights or periocular ( . 2021 Jul 1;12(4):1010-1020. doi: 10.14336/AD.2021.0216. Photic stimulation (PS): is a series of brief, brilliant light flashes. Clin Electroencephalogr. When a stimulus excites one part of the bodys parasympathetic nervous system, other parts of the system tend to become activated as well. In photosensitive JME subjects, we also performed a dynamic evaluation of BOLD signal changes evoked by the photoparoxysmal response (PPR) in a time frame ranging from 10 s before the onset of the EEG paroxysm up until 10 s afterward. Juvenile myoclonic epilepsy (JME) is a young-onset electroclinical syndrome, characterized by myoclonic, generalized tonic-clonic, and possibly typical absence seizures. Drug-free schizophrenic male patients (n=8, mean age=23.9) and normal male controls (n=11, mean age=24.3) were studied. Disclaimer, National Library of Medicine . Hyperventilation and photic stimulation are useful additions to a placebo-based suggestive seizure induction protocol in patients with psychogenic nonepileptic seizures. 2013 Jul;28 Suppl 1:S25-9. A seizure that lasts longer than 5 minutes, or having more than 1 seizure within a 5 minutes period, without returning to a normal level of consciousness between episodes is called status epilepticus. We A two-month-old girl brought to the neurology clinic by her parents with complaints of seizure-like activities was noted to have a normal interactive smile and visual tracking and an abnormal electroencephalogram (EEG) report, performed in a different laboratory, which showed an asymmetric photic driving response. And it is high incidence and an aggravation factor of migraine attack. Accessibility Although light deprivation or irregular or aberrant light exposure, which causes abnormal light/dark cycles, can adversely affect mood and cognitive functioning [ 15 - 19 ], appropriate photic stimulation can potentially exert antidepressant effects in humans and in animal models of depression [ 12, 20 - 25 ]. Abnormal EEG responses to photic stimulation in schizophrenic patients. Driving: The same type of conditions with flickering lights that might trigger a seizure at the fireworks may occur with driving either at night or riding in a car along a line of trees with low setting sunlight, creating that flickering or dappled light effect. The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity. [Left hemispheric site of EEG findings in patients with schizophrenic psychoses]. Psychiatr Neurol Med Psychol (Leipz). . IPS and EEGs are often used to diagnose conditions such as photosensitive epilepsy. Sustained versus transient brain responses in schizophrenia: the role of intrinsic neural activity. Although large eye movements could be excluded as confounding factors, the filter could not for certain exclude small eye movements. The site is secure. Schizophrenic patients had decreased sensitivity to the photic stimulation in the alpha range for spectra derived from both fundamental and harmonic analysis.". In adults, the common causes are: Stroke. A significant difference was found between the groups both at rest and following photic stimulation in EEG activity. T1 - Abnormal EEG responses to photic stimulation in schizophrenic patients. The BOLD response to IPS was investigated both in JME and control groups. Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity. The hypothesis that the amount of EEG alpha activity, particularly its synchronization to the external stimuli, could reflect the thalamic function in sensory information processing in schizophrenia is supported. Kim KY, Moon JU, Lee JY, Eom TH, Kim YH, Lee IG. Subjects were instructed to keep their eyes closed throughout. Subjects were instructed to keep their eyes closed throughout. The EEG effects of tobacco smoking--a review. Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. A significant difference was found between the groups both at rest and following photic stimulation in EEG activity. Moon JU, Lee JY, Kim KY, Eom TH, Kim YH, Lee IG. FOIA Photic driving: a. is an abnormal response to photic stimulation A two-month-old girl was brought to the neurology clinic by her parents with . In ad- 1994;244(5):247-51. doi: 10.1007/BF02190377. 1995;21(2):263-8. doi: 10.1093/schbul/21.2.263. Hyperventilation (HV) is an activation technique used during EEG recording to elicit epileptiform abnormalities, and in some cases seizures, in order to enhance the diagnostic sensitivity of EEG. Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis. government site. AB - Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. The patients with paranoid schizophrenia were found to show significantly greater coherence reactivity to photic stimulation, and the results suggest that schizophrenic patients have excessive functional reorganization between hemispheres in association withPhotic stimulation. 1 : of, relating to, or involving light especially in relation to organisms. Neurophysiology of juvenile myoclonic epilepsy: EEG-based network and graph analysis of the interictal and immediate preictal states. Keywords: The ones with a PPR belonged Intermittent Photic Stimulation (IPS) denote as all to the focal epilepsy group. A precise diagnosis can be made in a controlled environment using intermittent photic stimulation (IPS) and monitoring brain activity with an electroencephalogram (EEG) [ 15 ]. Jin, Y, Potkin, SG, Rice, D, Sramek, J, Costa, J, Isenhart, R, Heh, C & Sandman, CA 1990, '. Epub 2004 Jun 16. Recent research has shown that the complex connection between the eye and the brain is an important key to the disease. Photosensitive seizures are triggered by flashing or flickering lights. Although large eye movements could be excluded as confounding factors, the filter could not for certain exclude small eye movements. MTLE accounts for almost 80% of all temporal lobe seizures. The .gov means its official. Electrodermal and emotional lability measures were assessed by nonspecific skin conductance response and the Maudsley Personality . Where is H. pylori most commonly found in the world? 2006 Jul;32(3):556-61. doi: 10.1093/schbul/sbj020. Lifelines Neuro's Photic Stimulator combines the brightness of a Xenon flash with the utility and ease-of-use of an LED device. MeSH Epub 2011 Aug 11. Juvenile myoclonic epilepsy and idiopathic photosensitive occipital lobe epilepsy: is there overlap? Our aim was to explore the blood oxygen level-dependent (BOLD) response evoked by a highly provocative photic stimulus in a cohort of people with JME compared to a group of nonphotosensitive healthy controls, and to investigate the hemodynamic phenomena seen in patients with photosensitive JME. /. title = "Abnormal EEG responses to photic stimulation in schizophrenic patients". The results, which replicate earlier findings of increased delta activity in schizophrenia, emphasize the importance of excluding the slow activity due to eye movement in the comparisons of summed EEG spectra. Clipboard, Search History, and several other advanced features are temporarily unavailable. Jin Y, Potkin SG, Kemp AS, Huerta ST, Alva G, Thai TM, Carreon D, Bunney WE Jr. Schizophr Bull. Subjects were 16 healthy males divided into a photic stimulation group (n=8) and a control group (n=8). Glaucoma shares a number of features with degenerative brain diseases such as Alzheimer's, Parkinson's, and Lou Gehrig's disease. Would you like email updates of new search results? Clozapine increases EEG photic driving in clinical responders. 2022 Feb 9;22(1):48. doi: 10.1186/s12883-022-02577-6. Kasteleijn-Nolst Trenit DG, de Weerd A, Beniczky S. Epilepsy Behav. Photic stimulation, while . Psychiatr Neurol Med Psychol (Leipz). Typically, this interictal activity is generalized or focal occipital, arises during but outlasts the photic stimulation . It is time locked to the flash frequency during photic stimulation. We studied 13 JME patients and 18 healthy controls using EEG-functional magnetic resonance imaging (fMRI) performed during low luminance intermittent photic stimulation (IPS). The EEG activity following the photic driving also differentiated the groups. Abstract. Would you like email updates of new search results? Status epilepticus (SE) is a very severe type of seizure. b. during photic stimulation c. during stage-1 sleep d. during REM sleep Normal alpha, in an adult, should NOT be seen: a. in the central and temporal head regions b. with the eyes closed c. in the frontal head regions d. in the occipital head regions . Bethesda, MD 20894, Web Policies Eighty seconds of EEG were collected from each subject for each of four experimental conditions: one resting and three photic-driving conditions (2.38, 4.54, and 8.33 Hz). Posterior destructive lesions are particularly likely to attenuate the driving response, but some reports have described an enhanced photic response on the side of dysfunction. Schizophrenic patients had decreased sensitivity to the photic stimulation in the alpha range for spectra derived from both fundamental and harmonic analysis. Intermittent photic stimulation (IPS) is a common procedure performed in the electroencephalography (EEG) laboratory in children and adults to detect abnormal epileptogenic sensitivity to flickering light (i.e., photosensitivity). Normal photic driving has long been known to be potentially reduced on the side of a lesion. @article{4da3e20980be4fd1842e968c86878940. The photic driving response and the photic hypersensitivity are similar as both are induced by light stimulation. Ideal for photic activation during EEG studies. When the background becomes too organized--including via periodicity--this raises suspicion for abnormal synchronous firing of neurons. This is a medical emergency that may lead to permanent brain damage or death. Talk to our Chatbot to narrow down your search. }", University of Texas Southwestern Medical Center Home, Abnormal EEG responses to photic stimulation in schizophrenic patients. Aging Dis. This result was characterized by increased delta activity and decreased alpha activity in schizophrenic patients at rest. An abnormal response to photic stimulation can be seen in focal lesions. Subjects were instructed to keep their eyes closed throughout. author = "Yi Jin and Potkin, {Steven G.} and Dan Rice and John Sramek and Jerome Costa and Robert Isenhart and Chris Heh and Sandman, {Curt A. Slowing may be intermittent or persistent, with more persistent or consistently slower activity generally indicating more severe underlying focal cerebral dysfunction. Yi Jin, Steven G. Potkin, Dan Rice, John Sramek, Jerome Costa, Robert Isenhart, Chris Heh, Curt A. Sandman, Research output: Contribution to journal Article peer-review. The effect of EEG-driven photic stimulation on stress-related endocrine function was studied. Patients with LGS experience many different types of seizures including: Tonic stiffening of the body. Schizophr Res. 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