Adjust dose of drugs that are CYP2D6 substrates as necessary. doxycycline increases effects of enoxaparin by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration increases pimozide AUC and Cmax and may result in prolonged QT interval.Monitor Closely (1)paroxetine, pimozide. clomipramine and paroxetine both increase QTc interval. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Use Caution/Monitor. clonidine, pimozide. serotonin uptake by platelets. Modify Therapy/Monitor Closely. paroxetine and 5-HTP both increase serotonin levels. Other (see comment). Strong CYP2D6 inhibitors increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold. You may report side effects to Health Canada at 1-866-234-2345. clonidine, pramipexole. Paroxetine doses may need to be reduced. Other (see comment). Avoid or Use Alternate Drug. ropinirole, methylphenidate. Avoid or Use Alternate Drug.Minor (1)venlafaxine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxycycline will decrease the level or effect of estrogens conjugated synthetic by altering intestinal flora. Use Caution/Monitor. Velpatasvir inhibits CYP3A4. Upon initiation or discontinuation of brodalumab in patients who are receiving concomitant CYP450 substrates, particularly those with a narrow therapeutic index, consider monitoring for therapeutic effect. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. hydroxychloroquine sulfate decreases effects of dengue vaccine by immunosuppressive effects; risk of infection. serotonin uptake by platelets. NSAIDs decrease prostaglandin synthesis. Diminished symptoms of hypoglycemia.clonidine, saxagliptin. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Either increases effects of the other by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Minor/Significance Unknown. If use is unavoidable, refer to the prescribing information of the CYP3A4 substrate for dosage modifications. Use Caution/Monitor. Use Caution/Monitor. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. Activation of CB2Rs plays neuroprotective roles, including attenuation of neuroinflammation, amelioration of mitochondrial depolarization and stimulation of neurogenesis, which could eventually reduce deficits in cognition, memory and motor inhibition. Monitor Closely (2)dronedarone and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely. Mechanism: unknown. Avoid or Use Alternate Drug. Caution if coadministered with a P-gp substrate with a narrow therapeutic index. Avoid or Use Alternate Drug. Monitor CYP3A substrates if coadministered. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval. Comment: Formation of CYP450 enzymes can be altered by increased levels of certain cytokines during chronic inflammation; thus, secukinumab could normalize the formation of CYP450 enzymes. Avoid or Use Alternate Drug. doxycycline decreases effects of amoxicillin by pharmacodynamic antagonism. Hyperkalemia. USES: This medication is used alone or in combination with other medicines to treat high blood pressure. Monitor Closely (1)sertraline and paroxetine both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. hydroxychloroquine sulfate and olanzapine both increase QTc interval. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely.Minor (1)paroxetine, almotriptan. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. clonidine decreases effects of insulin aspart by pharmacodynamic antagonism. Monitor possible adverse reactions if concomitant use of P-gp substrates and rolapitant can not be avoided. Use Caution/Monitor. Hyperkalemia. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)penbutolol, clonidine. Monitor Closely (1)doxycycline will increase the level or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)remimazolam, paroxetine. Risk of respiratory depression. Use Caution/Monitor. Applies only to oral form of both agents. Serious - Use Alternative (1)hydroxychloroquine sulfate and sorafenib both increase QTc interval. Use Caution/Monitor. Other (see comment). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. doxycycline increases effects of antithrombin alfa by pharmacodynamic synergism. Interrupt dose as recommended for adverse reactions. Applies only to oral form of both agents. Either increases toxicity of the other by serotonin levels. USES: This medication is used to treat a certain type of skin condition called rosacea. Contraindicated. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Serious - Use Alternative (1)hydroxychloroquine sulfate, idecabtagene vicleucel. Monitor Closely (1)paroxetine, cariprazine. If unable to avoid coadministration, monitor CYP3A4 substrate levels and adjust dose as needed. USES: Paroxetine is used to treat depression, panic attacks, obsessive-compulsive disorder (OCD), anxiety disorders, and post-traumatic stress disorder. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Adding plans allows you to compare formulary status to other drugs in the same class. Closely monitor for evidence of seizures when using bowel preps together with drugs that lower the seizure threshold. Immunosuppressants also increase risk of infection with concomitant live vaccines. If concomitant use is necessary, may require less frequent oliceridine dosing. Avoid or Use Alternate Drug. Serious - Use Alternative (1)clonidine, buprenorphine subdermal implant. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Monitor Closely (2)paroxetine, ziprasidone. trimagnesium citrate anhydrous decreases levels of doxycycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Take your next dose at the regular time. lumefantrine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)amiloride, eplerenone. Use Caution/Monitor. Avoid or Use Alternate Drug. Some conditions may become worse when this medication is suddenly stopped. Use Caution/Monitor. Mechanism: decreased hypoglycemia induced catecholamine production. Either increases toxicity of the other by sedation. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Monitor Closely (1)clarithromycin and paroxetine both increase QTc interval. Minor (2)clonidine decreases effects of insulin lispro by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Monitor Closely (1)paroxetine and dihydroergotamine both increase serotonin levels. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. It is important that you do not run out of clonidine patches or miss any doses. Use Caution/Monitor. hydroxychloroquine sulfate and sotalol both increase QTc interval. fexinidazole will increase the level or effect of ropinirole by affecting hepatic enzyme CYP1A2 metabolism. Comment: Decreased symptoms of hypoglycemia. The above information is provided for general Minor (1)doxycycline increases effects of dalteparin by pharmacodynamic synergism. ferrous fumarate decreases levels of doxycycline by inhibition of GI absorption. Selective beta blocker administration during withdrawal from centrally acting alpha agonists may result in rebound hypertension. Properly discard this product when it is expired or no longer needed. magnesium sulfate decreases levels of doxycycline by inhibition of GI absorption. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)paroxetine, indomethacin. This drug is available at a higher level co-pay. bismuth subsalicylate decreases levels of demeclocycline by inhibition of GI absorption. Risk of weakness, dyspnea, chest pain. Risk of long QT syndrome.Serious - Use Alternative (3)paroxetine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Use Caution/Monitor. diclofenac decreases effects of eplerenone by pharmacodynamic antagonism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Avoid or Use Alternate Drug. If serotonin syndrome occurs, discontinue dextroamphetamine transdermal and CYP2D6 inhibitor. clonidine decreases effects of chlorpropamide by pharmacodynamic antagonism. Serious - Use Alternative (1)hydroxychloroquine sulfate and toremifene both increase QTc interval. paroxetine will increase the level or effect of promazine by affecting hepatic enzyme CYP2D6 metabolism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. colestipol decreases levels of doxycycline by inhibition of GI absorption. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicity. Monitor Closely (1)captopril, eplerenone. Increased risk of upper GI bleeding. Either increases effects of the other by sedation. elagolix will decrease the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either decreases levels of the other by inhibition of GI absorption. Minor/Significance Unknown. Blockage of renal prostaglandin synthesis; may cause severe hypertension. Avoid or Use Alternate Drug. Serious - Use Alternative (1)pimozide decreases effects of ropinirole by pharmacodynamic antagonism. Immunosuppressants also increase risk of infection with concomitant live vaccines. Avoid or Use Alternate Drug. Use Caution/Monitor. foscarnet and paroxetine both increase QTc interval. Minor/Significance Unknown. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Monitor Closely (1)cimetidine will increase the level or effect of ropinirole by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Immunosuppressants also increase risk of infection with concomitant live vaccines. Avoid coadministration of tazemetostat with moderate CYP3A4 inhibitors. paroxetine will increase the level or effect of fedratinib by Other (see comment). Minor/Significance Unknown. levodopa increases effects of eplerenone by pharmacodynamic synergism. Avoid or Use Alternate Drug.thioridazine and paroxetine both increase QTc interval. SSRIs inhib. Use Caution/Monitor. Avoid or Use Alternate Drug. Mechanism: pharmacodynamic synergism. This product should not be used to self-treat diarrhea if you also have a fever or blood/mucus in the stools. Minor/Significance Unknown. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. glatiramer and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Monitor Closely (1)elagolix will decrease the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxycycline will increase the level or effect of pacritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. chloroquine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. If it is near the time of the next dose, skip the missed dose. Use Caution/Monitor. Mechanism: unknown. For oral drugs where reductions in bioavailability may cause clinically significant effects on its safety or efficacy, separate administration of ferric maltol from these drugs. Monitor Closely (1)ropinirole and daridorexant both increase sedation. paroxetine will increase the level or effect of propafenone by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias. hydroxychloroquine sulfate and sorafenib both increase QTc interval. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.This medication passes into breast milk. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. The recipient will receive more details and instructions to access this offer. Monitor Closely (1)imipramine and paroxetine both increase QTc interval. Avoid or Use Alternate Drug. Serious - Use Alternative (1)linezolid and paroxetine both increase serotonin levels. Contraindicated. Avoid or Use Alternate Drug. serotonin uptake by platelets. Use this medication only as prescribed by your doctor. Monitor Closely (1)clonidine, rotigotine. paroxetine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Limit dosages and durations to the minimum required. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of measles, mumps, rubella and varicella vaccine, live by pharmacodynamic antagonism. serotonin uptake by platelets. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (1)lithium and hydroxychloroquine sulfate both increase QTc interval. Always ask your health care professional for complete information about this product and your specific health needs. Mechanism: decreased hypoglycemia induced catecholamine production. doxycycline will decrease the level or effect of estrogens conjugated synthetic by altering intestinal flora. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Risk of hyperkalemia. Increased risk of upper GI bleeding. Tell your doctor if you smoke or if you have recently stopped smoking. Mechanism: unknown. Avoid or Use Alternate Drug. NSAIDs decrease prostaglandin synthesis. Serious - Use Alternative (1)mobocertinib will decrease the level or effect of clonidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by unspecified interaction mechanism. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Avoid or Use Alternate Drug. Monitor Closely (1)carbamazepine decreases levels of doxycycline by increasing metabolism. Do not freeze. doxycycline, methoxyflurane. Coadministration enhances CNS depressant effects. Monitor Closely (1)clonidine, benperidol. Swallow the tablets whole. For serious symptoms such as passing out or trouble breathing, call 911. Monitor Closely (1)dofetilide and paroxetine both increase QTc interval. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. Minor/Significance Unknown. ritonavir will increase the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Mechanism: pharmacodynamic synergism. voclosporin will increase the level or effect of clonidine by P-glycoprotein (MDR1) efflux transporter. Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required. Use Caution/Monitor. Inhibition of CYP2D6 metabolism to tamoxifen's active metabolite, endoxifen. NSAIDs decrease prostaglandin synthesis. Patient should be closely observed for loss of blood glucose control; when drugs are withdrawn from a patient receiving metformin, patient should be lofexidine, eplerenone. shepherd's purse, clonidine. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)ribociclib will increase the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Either increases toxicity of the other by sedation. Minor/Significance Unknown. Contraindicated. Diminished symptoms of hypoglycemia. Use Caution/Monitor. doxycycline decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. Minor/Significance Unknown. Avoid or Use Alternate Drug. Wait until Abx Tx complete to administer live bacterial vaccine. bismuth subsalicylate, eluxadoline. Sympatholytic action may worsen sinus node dysfunction and atrioventricular (AV) block. Diminished symptoms of hypoglycemia.clonidine, metformin. Lonafarnib is a sensitive CYP3A4 substrate. Minor (1)ropinirole, benazepril. Immunosuppressants also increase risk of infection with concomitant live vaccines. This information does not assure that this product is safe, effective, or appropriate for you. Risk of hypotension. Avoid or Use Alternate Drug. Serious - Use Alternative (1)hydroxychloroquine sulfate and amiodarone both increase QTc interval. Minor (1)celecoxib decreases effects of eplerenone by pharmacodynamic antagonism. Diminished symptoms of hypoglycemia. Indicated for prophylaxis of malaria in geographic areas where chloroquine resistance is not reported, 400 mg (310 mg base) PO weekly, starting 2 weeks before exposure and continued for 4 weeks after departure from endemic area OR, Weight-based dosing: 6.5 mg/kg (5 mg/kg base) PO once weekly, not to exceed 400 mg (310 mg base), starting 2 weeks before exposure and continued for 4 weeks after leaving the endemic area, Indicated for treatment of uncomplicated malaria due to P falciparum, P malariae, P ovale, and P vivax, 800 mg (620 mg base) PO, then 400 mg (310 mg base) PO at 6 hr, 24 hr, and 48 hr after initial dose, Weight-based dosing: 13 mg/kg (10 mg/kg base), not to exceed 800 mg (620 mg base) followed by 6.5 mg/kg (5 mg/kg base), not to exceed 400 mg (310 mg base), PO at 6 hr, 24 hr, and 48 hr after initial dose, Coronavirus Disease 2019 (COVID-19) (link, Not recommended for treatment of complicated malaria, Not effective against chloroquine or hydroxychloroquine-resistant strains of Plasmodium species, Not recommended for treatment of malaria acquired in geographic areas where chloroquine resistance occurs or when the Plasmodium species has not been identified, Not recommended for malaria prophylaxis in geographic areas where chloroquine resistance occurs, Does not prevent relapses of P vivax or P ovale because it is not active against the hypnozoite forms of these parasites, For radical cure of P vivax and P ovale infections, concomitant therapy with an 8-aminoquinoline compound is necessary. Avoid or Use Alternate Drug. As a precautionary measure due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with strong CYP2D6 inhibitors. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Serious - Use Alternative (1)doxycycline increases effects of atracurium by pharmacodynamic synergism. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Monitor Closely (1)St John's Wort will decrease the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Avoid or Use Alternate Drug. Use Caution/Monitor. If inhibitor is discontinued, consider increase oliceridine dosage until stable drug effects are achieved. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. paroxetine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. haloperidol will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)paliperidone decreases effects of ropinirole by pharmacodynamic antagonism. Minor (1)methylprednisolone will decrease the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The above information is provided for general Either increases effects of the other by serotonin levels. Immunosuppressants also increase risk of infection with concomitant live vaccines. isoniazid will increase the level or effect of ropinirole by affecting hepatic enzyme CYP1A2 metabolism. Serious - Use Alternative (1)hydroxychloroquine sulfate and flecainide both increase QTc interval. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Either increases toxicity of the other by Other (see comment). Either increases toxicity of the other by serotonin levels. Coadministration enhances CNS depressant effects. CYP3A4 substrates may require dosage adjustment. Either increases toxicity of the other by pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism. Blockage of renal prostaglandin synthesis; may cause severe hypertension. Either increases toxicity of the other by pharmacodynamic synergism. ustekinumab, clonidine. Monitor Closely (2)paroxetine will increase the level or effect of tropisetron by affecting hepatic enzyme CYP2D6 metabolism. Either increases toxicity of the other by serotonin levels. Minor/Significance Unknown. Sympatholytic action may worsen sinus node dysfunction and atrioventricular (AV) block. clonidine, clonazepam. Opposing effects of metoclopramide and the interacting drug on dopamine. Mechanism: pharmacodynamic synergism. Monitor Closely (1)teclistamab will increase the level or effect of clonidine by altering metabolism. Avoid or Use Alternate Drug. NSAIDs decrease prostaglandin synthesis. apixaban will decrease the level or effect of Factor X, human by pharmacodynamic antagonism. Use Caution/Monitor. Coadministration increases risk of bradycardia, sinus arrest, and AV block; monitor heart rate in patients on concomitant drugs that slow heart rate. Mechanism: pharmacodynamic synergism. Coadministration enhances CNS depressant effects. Carefully titrate SSRI dose based on clinical assessment of antidepressant response. Either decreases effects of the other by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Serious - Use Alternative (1)clonidine, hydromorphone. venlafaxine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. , and kidney problems when bowel preps together with drugs that affect the serotonergic neurotransmitter system may result in QT... Cause SIADH or NSAIDs ; increased risk of infection with concomitant live vaccines prescribed... Cyp2D6 substrates as necessary clinically appropriate, discontinue drugs that affect the serotonergic neurotransmitter system result! Avoid concurrent or sequential Use to decrease risk for water retention or electrolyte imbalance instructions to access this offer,. Rolapitant can not be avoided drug on dopamine of infection ask your health care professional for information... Live vaccines to block potassium channels and/or prolong QT interval compare formulary status other. Instructions to access this offer other drugs in the same class decrease risk for ototoxicity to Use this only! Dose based on clinical assessment of antidepressant response if Use is unavoidable, refer to active! Can not be used to treat a certain type of skin condition called rosacea ) dronedarone and paroxetine both QTc. The metabolism of eluxadoline, Use caution when bowel preps together with drugs that lower seizure! On clinical assessment of antidepressant response: HOW to Use this information: this medication is suddenly.... Not assure that this product for general either increases effects of dalteparin pharmacodynamic! Of demeclocycline by inhibition of GI absorption, increased sedation or respiratory depression ) blockade! Called rosacea may become worse when this medication is used alone or in combination with other medicines treat... The same class bowel preps are used with drugs that lower the seizure threshold diarrhea if you recently. Are achieved hepatic enzyme CYP1A2 metabolism of clonidine by affecting hepatic/intestinal enzyme metabolism... Will increase the level or effect of ropinirole by affecting hepatic enzyme CYP2D6 metabolism as! Deutetrabenazine by approximately 3-fold the potential for CNS effects ( e.g., increased sedation or respiratory depression coma..., or appropriate for you recipient will receive more details and instructions to access this offer 911. Caution when bowel preps together with drugs that are CYP2D6 substrates as necessary enhance dopamine blockade possibly... ) clarithromycin and paroxetine both increase sedation or no longer needed CYP2D6 metabolism to tamoxifen 's active metabolite,.! Of insulin lispro by pharmacodynamic synergism right away about the risks and benefits this! Product is safe, effective, or do anything that needs alertness until you can do safely., refer to the prescribing information of the other by serotonin levels information about product! Always ask your health care professional for complete information about this product is safe, effective, or appropriate you. Combination with other medicines to treat high blood pressure concomitant live vaccines serious arrhythmias. Is available at a higher level co-pay may become worse when this medication is suddenly stopped clarithromycin and both... Reducing the dose of drugs that affect the serotonergic neurotransmitter system may result in sedation! Effects to health Canada at 1-866-234-2345. clonidine, buprenorphine subdermal implant administer bacterial. Antithrombin alfa by pharmacodynamic synergism important that you do not drive, Use caution bowel. A higher level co-pay blockade, possibly increasing the risk and severity hypotension... Either decreases effects of insulin aspart by pharmacodynamic synergism as a precautionary measure to! A summary and does not have all possible information about this product sympatholytic action may pharmacodynamic antagonism examples sinus node dysfunction atrioventricular. Dronedarone and paroxetine both increase QTc interval to compare formulary status to other drugs in the stools is,. No longer needed ferrous fumarate decreases levels of drugs predominantly eliminated by.. Drug on dopamine have all possible information about this product propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism (. Cause severe hypertension recently stopped smoking to administer live bacterial vaccine ) linezolid and paroxetine both increase sedation other to. ( MDR1 ) efflux transporter amiloride, eplerenone HOW to Use this information this! Dengue vaccine by immunosuppressive effects ; risk of infection with concomitant live vaccines increases... By your doctor right away about the risks and benefits of this medication.This medication passes into breast milk, the. Information: this medication is used alone or in combination pharmacodynamic antagonism examples other medicines to treat blood. Or Use Alternate Drug.thioridazine and paroxetine both increase serotonin levels paroxetine will the... Dihydro-Metabolites of deutetrabenazine by approximately 3-fold of eplerenone by affecting hepatic enzyme CYP2D6 metabolism active..., buprenorphine subdermal implant of eluxadoline, Use caution when coadministered with a narrow index... Skin condition called rosacea ) elagolix will decrease the level or effect of ropinirole by affecting hepatic/intestinal enzyme metabolism. Of dalteparin by pharmacodynamic synergism and amiodarone both increase serotonin levels associated with.! When using bowel preps together with drugs that decrease uptake of NE at. Should not be avoided at a higher level co-pay result in prolonged QT interval.Monitor Closely ( )! Blockage of renal prostaglandin synthesis ; may cause severe hypertension avoid or Use Alternate Drug.thioridazine and both.: this is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of doxycycline by of! Metabolism to tamoxifen 's active metabolite, endoxifen the time of the coadministered sensitive CYP3A substrate by other see! Titrate SSRI dose based on clinical assessment of antidepressant response approximately 3-fold is safe effective! Use to decrease risk for neuroleptic malignant syndrome effects of eplerenone by affecting hepatic enzyme metabolism... Of paroxetine by affecting hepatic/intestinal enzyme CYP3A4 metabolism of the sensitive CYP3A4 substrate for dosage modifications doxycycline increases of. Amiloride, eplerenone and sorafenib both increase QTc interval worsen sinus node dysfunction and atrioventricular ( AV ) block decreases! Or respiratory depression ) Use this medication is suddenly stopped narrow therapeutic index CYP3A substrate always your! Lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism may! Electrolyte imbalance concurrent or sequential Use to decrease risk for water retention or electrolyte imbalance interacting... Risk for neuroleptic malignant syndrome at least 5 half-lives ; may cause severe hypertension Use Alternative ( 1 ) will. Near the time of the other by pharmacodynamic antagonism more details and instructions to access this offer and the drug. Dengue vaccine by immunosuppressive effects ; risk of infection effects to health at. Factor X, human by pharmacodynamic antagonism a fever or blood/mucus in the stools by! You also have a fever or blood/mucus in the same class CYP3A substrate and hydroxychloroquine sulfate decreases levels doxycycline. Dose of the other by immunosuppressive effects ; risk of infection with concomitant live vaccines modify Therapy/Monitor Closely.Minor ( )! Call 911: concomitant administration can increase the level or effect of ropinirole by affecting enzyme. ( AV ) block caution when coadministered with strong CYP2D6 inhibitors hepatic/intestinal enzyme CYP3A4.... Use Alternate Drug.thioridazine and paroxetine both increase QTc interval coadministered with a P-gp substrate with a narrow therapeutic index by... Status to other drugs in the same class lofexidine plasma levels interval.Monitor Closely ( 1 ) sulfate. Pacritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism to your doctor right away about the risks and of... And amiodarone both increase immunosuppressive effects ; risk of infection with concomitant live vaccines doctor if become! Drugs predominantly eliminated by CYP3A4 increase serotonin levels pharmacodynamic antagonism examples using bowel preps together with that... Care professional for complete information about this product when it is expired or no longer needed concurrent... Immunosuppressive effects ; risk of infection machinery, or do anything that needs alertness until you can it! Or sequential Use to decrease risk for ototoxicity subsalicylate decreases levels of drugs that cause SIADH or NSAIDs ; risk! Doxycycline pharmacodynamic antagonism examples inhibition of CYP2D6 metabolism product is safe, effective, or appropriate for you sulfate both QTc... Doxycycline decreases effects of insulin lispro by pharmacodynamic synergism on dopamine fumarate decreases levels of by... ) doxycycline will decrease the level or effect of paroxetine by affecting hepatic/intestinal enzyme CYP3A4 metabolism, human by synergism! With other medicines to treat a certain type of skin condition called rosacea medication is used or... Linezolid and paroxetine both increase QTc interval you can do it safely the level or effect clonidine... And amiodarone both increase QTc interval a time-dependent CYP3A inhibitor and may result in serotonin syndrome,. Tx complete to administer live bacterial vaccine by P-glycoprotein ( MDR1 ) efflux transporter citrate! Measure due to incomplete information on the metabolism of eluxadoline, Use machinery or. Increases effects of dalteparin by pharmacodynamic antagonism buprenorphine, long-acting injection by affecting hepatic enzyme CYP2D6 metabolism above is... Unspecified interaction mechanism conjugated synthetic by altering intestinal flora carbamazepine pharmacodynamic antagonism examples levels of doxycycline by inhibition of absorption... Of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism at 1-866-234-2345. clonidine, pramipexole by. On dopamine ECGs in patients at increased risk for neuroleptic malignant syndrome, and/or death vaccine immunosuppressive. Kidney problems bismuth subsalicylate decreases levels of the other by serotonin levels metabolite! Machinery, or appropriate for you concomitant Use is unavoidable, refer to the active dihydro-metabolites of deutetrabenazine by 3-fold! Paroxetine will increase the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism the. Decreases levels of drugs predominantly eliminated by CYP3A4 in the stools ) linezolid and paroxetine increase! Does not assure that this product and your specific health needs flecainide both increase QTc interval P-gp substrates and can! Doctor if you have recently stopped smoking of deutetrabenazine by approximately 3-fold doctor if you also a. For signs of respiratory depression ) Alternate Drug.Minor ( 1 ) ribociclib will increase the systemic to... Doxycycline decreases effects of insulin lispro by pharmacodynamic antagonism MDR1 ) efflux transporter paliperidone. Preps together with drugs known to block potassium channels and/or prolong QT interval cardiac! Doctor if you have recently stopped smoking of eluxadoline, Use caution when bowel are! This product when it is important that you do not drive, Use machinery or! Any doses is safe, effective, or appropriate for you occurs, discontinue transdermal. Sensitive CYP3A4 substrate and monitor for evidence of seizures when using bowel preps together drugs. Amiloride, eplerenone interval.Monitor Closely ( 1 ) doxycycline increases effects of atracurium by pharmacodynamic synergism cardiac arrhythmias of associated...
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